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Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.

by on February 12, 2019

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Date of publication: February, 2019

Publication type: Systematic Review

In a nutshell:

The review found some evidence (based on eight small trials) that individuals taking lamotrigine are more likely to be seizure free than those using placebos. The review found robust evidence that patients taking ethosuximide or valproate are more likely to be seizure free than those using lamotrigine. However, because of the lower risk of adverse effects, the use of ethosuximide is preferred over valproate in patients with absence childhood epilepsy. With regards to both efficacy and tolerability, ethosuximide represents the optimal initial empirical monotherapy for children and adolescents with absence seizures.

Some important notes: In case you experience difficulty obtaining this review,  please ask your local health librarian to locate this for you.

 

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